Research Library
Written by the Relief Team · Lifestyle

The Let-Down Effect: Saturday Migraines

Surviving a stressful 50-hour week only to be hit by a debilitating attack on Saturday morning — this is the Let-Down Effect.

The Cortisol and Adrenaline Factor

During stress, your body runs in fight-or-flight mode with high cortisol. When you relax, cortisol crashes. This sudden drop triggers blood vessel dilation in the brain, leading to inflammation. Maintaining a consistent wake-up time on weekends helps keep your circadian rhythm stable and prevents the crash.

Related Guides

Weather & Barometric Pressure

How atmospheric shifts trigger attacks.

The 4 Migraine Phases

From warning signs to recovery.

Track Your Triggers

The Relief app correlates your attacks with weather, sleep, food, and more — automatically.

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