CGRP (Calcitonin Gene-Related Peptide) is a protein released during a migraine that causes massive inflammation in the brain's blood vessels. For decades, we used drugs meant for blood pressure or seizures. CGRP Inhibitors are the first class designed specifically to block this molecule.
Monthly injections like Aimovig (Erenumab), Emgality, and Ajovy bind to CGRP or its receptor, preventing it from triggering inflammation. Because they are targeted, they often have far fewer side effects than older treatments.
Medications like Rimegepant (Nurtec) and Ubrogepant (Ubrelvy) can be used for both acute rescue and prevention. They don't cause vasoconstriction, making them safe for patients with cardiovascular history.
Even with newer drugs, using acute medications more than 10–15 days per month can trigger rebound headaches. A proper tracking system is essential to stay under the clinical threshold.
The Relief app correlates your attacks with weather, sleep, food, and more — automatically.
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