Botox (OnabotulinumtoxinA) is FDA-approved specifically for Chronic Migraine — defined as 15 or more headache days per month. The procedure involves 31 specific injection points across the head, neck, and shoulders every 12 weeks.
Botox enters nerve endings near the injection site and blocks the release of chemicals that transmit pain signals — including CGRP and glutamate. It takes about 2 to 3 treatment cycles (6–9 months) to reach maximum effectiveness, but many chronic sufferers see a 50% reduction in attack frequency.
A MIDAS score of 21+ (Grade IV) combined with chronic migraine diagnosis is typically required for insurance approval. Documenting your attack frequency with a tracker provides the clinical evidence your neurologist needs.
The Relief app correlates your attacks with weather, sleep, food, and more — automatically.
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